Angiotensin

This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. Find sources: "Angiotensin" – news · newspapers · books · scholar · JSTOR (March 2020) (Learn how and when to remove this message)

AGT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WXW, 2X0B, 4APH,%%s1N9U, 1N9V,%%s1N9V, 1N9U, 3CK0, 4AA1, 4APH, 5E2Q
Identifiers
Aliases	AGT, ANHU, SERPINA8, hFLT1, angiotensinogen
External IDs	MGI: 87963; HomoloGene: 14; GeneCards: AGT; OMA:AGT - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.2 Start 230,690,776 bp[1] End 230,745,576 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 E2|8 72.81 cM Start 125,283,273 bp[2] End 125,296,445 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in liver right lobe of liver external globus pallidus dorsal motor nucleus of vagus nerve superior vestibular nucleus pars reticulata paraflocculus of cerebellum inferior olivary nucleus ventral tegmental area amygdala Top expressed in left lobe of liver parotid gland lumbar subsegment of spinal cord paraventricular nucleus of hypothalamus central gray substance of midbrain deep cerebellar nuclei dorsal tegmental nucleus superior colliculus globus pallidus medulla oblongata More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding serine-type endopeptidase inhibitor activity type 1 angiotensin receptor binding hormone activity superoxide-generating NADPH oxidase activator activity growth factor activity type 2 angiotensin receptor binding sodium channel regulator activity angiotensin receptor binding receptor ligand activity Cellular component cytoplasm extracellular exosome blood microparticle extracellular space cytosol extracellular region collagen-containing extracellular matrix Biological process uterine smooth muscle contraction renal system process vasoconstriction positive regulation of catalytic activity positive regulation of cardiac muscle hypertrophy cell surface receptor signaling pathway cellular response to mechanical stimulus stress-activated MAPK cascade artery smooth muscle contraction regulation of systemic arterial blood pressure by renin-angiotensin regulation of apoptotic process negative regulation of neurotrophin TRK receptor signaling pathway regulation of long-term neuronal synaptic plasticity positive regulation of renal sodium excretion positive regulation of fibroblast proliferation cellular sodium ion homeostasis ERK1 and ERK2 cascade activation of phospholipase C activity angiotensin maturation positive regulation of extracellular matrix constituent secretion positive regulation of blood pressure negative regulation of cell growth regulation of norepinephrine secretion female pregnancy negative regulation of tissue remodeling regulation of heart rate smooth muscle cell proliferation regulation of calcium ion transport regulation of transmission of nerve impulse cell growth involved in cardiac muscle cell development response to muscle activity involved in regulation of muscle adaptation positive regulation of nitric oxide biosynthetic process angiotensin-mediated drinking behavior cell-cell signaling human ageing vasodilation positive regulation of cell population proliferation fibroblast proliferation negative regulation of angiogenesis positive regulation of superoxide anion generation positive regulation of L-lysine import across plasma membrane positive regulation of cardiac muscle cell apoptotic process positive regulation of vascular associated smooth muscle cell proliferation positive regulation of cytosolic calcium ion concentration negative regulation of endopeptidase activity positive regulation of vascular associated smooth muscle cell migration regulation of molecular function regulation of lipid metabolic process positive regulation of L-arginine import across plasma membrane regulation of signaling receptor activity positive regulation of neuron projection development response to estradiol cellular response to angiotensin protein import into nucleus associative learning operant conditioning positive regulation of insulin receptor signaling pathway regulation of extracellular matrix assembly positive regulation of cholesterol esterification phospholipase C-activating G protein-coupled receptor signaling pathway blood vessel remodeling positive regulation of reactive oxygen species metabolic process positive regulation of extrinsic apoptotic signaling pathway positive regulation of protein metabolic process positive regulation of branching involved in ureteric bud morphogenesis kidney development positive regulation of transcription, DNA-templated positive regulation of peptidyl-tyrosine phosphorylation positive regulation of inflammatory response positive regulation of protein tyrosine kinase activity regulation of blood pressure positive regulation of macrophage derived foam cell differentiation regulation of vasoconstriction positive regulation of NF-kappaB transcription factor activity positive regulation of NAD(P)H oxidase activity nitric oxide mediated signal transduction G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger positive regulation of epidermal growth factor receptor signaling pathway regulation of blood volume by renin-angiotensin regulation of cardiac conduction maintenance of blood vessel diameter homeostasis by renin-angiotensin regulation of renal sodium excretion positive regulation of cytokine production positive regulation of membrane hyperpolarization negative regulation of sodium ion transmembrane transporter activity renin-angiotensin regulation of aldosterone production positive regulation of endothelial cell migration low-density lipoprotein particle remodeling regulation of cell population proliferation regulation of cell growth positive regulation of gap junction assembly positive regulation of phosphatidylinositol 3-kinase signaling angiotensin-activated signaling pathway negative regulation of gene expression regulation of renal output by angiotensin positive regulation of activation of Janus kinase activity G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 183 11606 Ensembl ENSG00000135744 ENSMUSG00000031980 UniProt P01019 P11859 Q3UTR7 RefSeq (mRNA) NM_000029 NM_001382817 NM_001384479 NM_007428 RefSeq (protein) NP_000020 NP_001369746 NP_031454 Location (UCSC) Chr 1: 230.69 – 230.75 Mb Chr 8: 125.28 – 125.3 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Angiotensin is a peptide hormone that causes vasoconstriction and an increase in blood pressure. It is part of the renin–angiotensin system, which regulates blood pressure. Angiotensin also stimulates the release of aldosterone from the adrenal cortex to promote sodium retention by the kidneys.

An oligopeptide, angiotensin is a hormone and a dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. Angiotensin was isolated in the late 1930s (first named 'angiotonin' or 'hypertensin') and subsequently characterized and synthesized by groups at the Cleveland Clinic and Ciba laboratories.^[5]